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Irbesartan prevents angiotensin II binding to your AT1 receptor in tissues like vascular smooth muscle mass along with the adrenal gland. Irbesartan and its Energetic metabolite bind the AT1 receptor with 8500 moments extra affinity than they bind for the AT2 receptor.
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Irbesartan does not inhibit ACE or renin or impact other hormone receptors or ion channels regarded to generally be involved in the cardiovascular regulation of blood pressure and sodium homeostasis.
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Angiotensin II would if not bind on the AT1 receptor, inducing vasoconstriction and aldosterone secretion, increasing blood pressure.
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